Jakarta, the body has a biological clock which controls the body what to do naturally. Set when the body's biological clock had to rest, need food or other activities conducted for 24 hours. Damage to the biological clock can damage the brain.
For the first time, scientists at Oregon State University found that disruption of the biological clock could accelerate brain cell damage, loss of motor function and premature death.
"Currently, many researchers are interested in the study of the biological clock or circadian rhythm, so also we are interested in learning about the various problems that can occur when the biological clock disrupted. In the end, we hope that this research can be taken from the laboratory and applied in the life real, "said the researcher, as reported by Rakshit Kuntol Scienceagogo.com, Monday (01/16/2012).
The study, published in the journal Neurobiology of Disease is done on fruit flies because it has some similarity with human genes. Several genes that regulate circadian rhythms in fruit flies have in common with humans, although it has gone through the process of evolution millions of years.
Biological clock in humans and other animals affect various biological processes, from fertility to the production of hormones, diet, DNA repair, sleep, stress reactions and even the effectiveness of the drug. In humans, researchers have found a strong relationship between the mechanisms of biological clocks are disrupted by aging and neurological diseases such as Alzheimer's disease (severe memory loss).
Fruit flies used in this study has undergone two mutations, one of the mutations disrupt circadian rhythms and other mutations cause the fly to have the disease because of the aging brain.
Double mutant flies have a lifespan of 32-50 percent shorter, loss of motor function and experienced a lot of vacuoles (holes in the brain) is much faster than a fly with a good biological clock. The researchers speculate that disruption of the biological clock that caused the damaging effects.
"The decline and loss of function of the biological clock may be just the beginning of a cycle of destructive processes. When the biological clock starts to break down, rhythms that regulate cell function and health to be impaired and we now know that this triggers nerve cell damage in the brain, which can lead to more much damage to the biological clock function, "explains co-researcher, Jadwiga Giebultowicz.
The researchers believe that a healthy biological clock may help protect against this damage.
"When the biological clock is broken, the damage process is accelerated. The aging process is closely related to this process, but it was unclear how the process is. Find a way to restore the biological clock could be a therapy to prevent damage to the biological clock and help prevent the progression of the disease," said Giebultowicz.
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